Pipeline 03 - InThera

Mosquito-borne infectious diseases according to climate change

“Outbreaks of emerging and mutant viruses, oversea inflow & the highest potential for pandemic due to climate change”

1A mosquito-borne infectious disease & Transmission through vertical transmission or blood transfusions
2Reported by 76 countries and continuous outbreaks since 2007
3Zika virus disease

- Zika fever (Fever, rash, muscle and joint pain, and red eyes) - Associated with Guillain-Barre Syndrome (GBS) - Microcephaly in the baby by infection during pregnancy
4No spontaneous infection in S. Korea, but concerns about oversea inflow due to continuous incidence in neighboring countries
5A pandemic-prone infectious disease WHO R&D Blueprint

- Included in the list of priority diseases - The goal is the preemptive R&D and quick response to outbreaks of the infectious diseases

Zika virus disease

Serious problems for the fetus by infection during pregnancy

Women of childbearing age including pregnant women, are the top priority for vaccination during a pandemic.

Included in R&D Blueprint in 2008 & Create TPP (target product profiles)

1A mosquito-borne infectious disease & Annually, about 300 million cases and 1 million deaths.

- Mainly prevalent in South-East Asia & Rapidly spread to US, Europe, Asia - WHO Health Emergencies Programme monitors the spread of dengue fever.
2Dengue virus disease

Dengue fever (DF),Dengue hemorrhagic fever (DHF), Dengue shock syndrome (DSS)
3
Severe symptoms, Emerging in new regions and increased incidence due to climate change, and fast spreading
→ The rapid development of an effective vaccine is needed.

- Pandemic-prone infectious disease - Notifiable disease group 4 in S. Korea

- Overseas traveler cases - 71.7% increase in 2019 compared to 2018

- Increase in habitat of Adese mosquitos in S. Korea according to climate change